Chromokinesin

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August undefined, 2024

WebMar 6, 2015 · The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles. J. Cell Biol. 154 , 1135–1146 (2001) . WebJul 24, 2024 · Here, we present a novel abscission mechanism. We identified chromokinesin KIF4A, which is adjacent to the midbody during cytokinesis, as being required for efficient abscission. KIF4A is regulated by post-translational modifications. We evaluated modification of KIF4A by the ubiquitin-like protein SUMO. We mapped lysine …

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Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebAug 14, 2010 · Chromokinesin KIF4 appears as reduced expression in human gastric carcinoma and associates with differentiation of gastric carcinoma. Chromokinesin KIF4 is previously reported to play an intriguing role in tumorigenesis [].To investigate the critical role of chromokinesin KIF4 in human gastric cancer, we examined 23 gastric carcinoma … how to start freelancing in pakistan

The human chromokinesin Kid is a plus end‐directed …

WebBackground: Despite the significant survival benefits of anti-PD-1/PD-L1 immunotherapy, non-small cell lung cancer (NSCLC) remains one of the most common tumors and major causes of cancer-related deaths worldwide. Thus, there is an urgent need to identify new therapeutic targets for this refractory disease. Methods: In this study, microarray datasets … WebJul 24, 2024 · (A) Chromokinesin KIF4A is required for the positioning of mitotic chromosomes and stabilization of the bipolar spindle. In cytokinesis, KIF4A localizes at … WebJun 27, 2024 · The chromokinesin KIF4A associates with microtubules and contributes to chromosome segregation during mitosis. Here, we show that this function depends on a … react flatten array

Chromokinesin KIF4A teams up with stathmin 1 to regulate ... - PubMed

WebSep 30, 2013 · Here we show that a quantum dot (Qdot) binding up to four Xenopus chromokinesin (Xkid) molecules behaved like a nanosize chromosome arm in the … WebThe chromokinesin KIF22 (Kid, kinesin-10 family) is the primary generator of polar ejection forces, which contribute to chromosome positioning and alignment in mitotic cells. Assessment of KIF22 function requires quantitative comparison of relative polar ejection forces between experimental conditions. This is facilitated by the generation of ... how to start freelancingWebGao J, Sai N, Wang C, et al. Overexpression of chromokinesin KIF4 inhibits proliferation of human gastric carcinoma cells both in vitro and in vivo. Tumour Biol. 2011;32(1):53–61. 20. Wu G, Zhou L, Khidr L, et al. A novel role of the chromokinesin Kif4A in DNA damage response. Cell Cycle. 2008;7(13):2013–2024. 21. react flex direction

"WebMar 6, 2015 · With regard to the kinetochore reaching the microtubule tip, CENP-E and chromokinesins are particularly important for chromosome movement to the spindle midzone in metazoans (Craske and Welburn,... " - Chromokinesin

Chromokinesin

WebJul 1, 2005 · Download : Download full-size image Figure 1. Molecular structure and cellular localization of chromokinesins. (a) Schematic domain structure of Kinesin-4 and Kinesin-10.(b) Localization of chromokinesin HKIF4A and effects on mitosis upon its loss. (top row) Human KIF4A localizes to the nucleus during interphase, associates with mitotic … WebMar 16, 2024 · The chromokinesin KIF22 generates forces that contribute to mitotic chromosome congression and alignment. Mutations in the α2 helix of the motor domain of KIF22 have been identified in patients with abnormal skeletal development, and we report the identification of a patient with a novel mutation in the KIF22 tail. We demonstrate that …

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WebJun 22, 2024 · The chromokinesin KIF22 generates forces that contribute to mitotic chromosome congression and alignment. Mutations in the α2 helix of the motor domain … WebMar 3, 2003 · The human chromokinesin Kid is a plus end-directed microtubule-based motor Junichiro Yajima Department of Life Sciences, Graduate School of Arts and …

WebSep 30, 2024 · The chromokinesin KIF22 uses plus end-directed motility and direct binding to chromosome arms to generate pushing forces that contribute to mitotic chromosome congression and alignment. Mutations in the motor domain of KIF22 have been identified in patients with abnormal skeletal development, and we report the identification of a patient … WebMar 3, 2003 · Kid is a kinesin-like DNA-binding protein known to be involved in chromosome movement during mitosis, although its actual motor function has not been demonstrated. Here, we describe the initial …

WebChromokinesins are microtubule plus end–directed motor proteins that bind to chromosome arms. In Xenopus egg cell-free extracts, Xkid and Xklp1 are essential for …

WebSep 30, 2013 · Here we show that a quantum dot (Qdot) binding up to four Xenopus chromokinesin (Xkid) molecules behaved like a nanosize chromosome arm in the meiotic spindle, which is self-organized in ...

WebApr 8, 2024 · This bias was impervious to the experimental attenuation of polar ejection forces on chromosome arms by RNAi against the chromokinesin Kif4a. Thus, kinetochore size is an important determinant of ... react flex growWebJan 1, 2024 · Abstract The chromokinesin KIF22 (Kid, kinesin-10 family) is the primary generator of polar ejection forces, which contribute to chromosome positioning and alignment in mitotic cells. Assessment of KIF22 function requires quantitative comparison of relative polar ejection forces between experimental conditions. react flatlist exampleWebSep 21, 2011 · Interestingly, from its positioning on the chromosome arms, Hklp2 seems to restrict spindle pole separation. In the present review, we summarize the current knowledge of the function and regulation of the different kinesins associated with chromosome arms during cell division, including Hklp2 as a novel member of this so-called chromokinesin ... how to start freelancing as web developerWebJul 1, 2005 · Figure 1 Molecular structure and cellular localization of chromokinesins. (a) Schematic domain structure of Kinesin-4 and Kinesin-10.(b) Localization of chromokinesin HKIF4A and effects on mitosis upon its loss. (top row) Human KIF4A localizes to the nucleus during interphase, associates with mitotic chromosomes during early mitosis and … react flickering renderWebOct 8, 2024 · Chromokinesins are members of the kinesin superfamily that harbour a specific DNA-binding domain. The best characterized chromokinesins belong to the … react flip move npmWebOct 8, 2024 · Chromokinesins are members of the kinesin superfamily that harbour a specific DNA-binding domain. The best characterized chromokinesins belong to the … react floating panelWebNational Center for Biotechnology Information react flexwrap